The Colorado River basin (CRB) is one of the most important watersheds for energy, water, and food security in the United States. CRB water supports 15% of U.S. food production, more than 50 GW of electricity capacity, and one of the fastest growing populations in the United States. Energy–water–food nexus impacts from climate change are projected to increase in the CRB. These include a higher incidence of extreme events, widespread snow-to-rain regime shifts, and a higher frequency and magnitude of climate-driven disturbances. Here, we empirically show how the historical annual streamflow maximum and hydrograph centroid timing relate to temperature, precipitation, and snow. In addition, we show how these hydroclimatic relationships vary with elevation and how the elevation dependence has changed over this historical observational record. To view the full article visit the Journal of Hydrometeorology.